As public health concern, HAdV infections are common and often cause acute diseases ranging from mild to severe, including death especially in immunocompromised individuals 2, 3, 4, 5, 6. Human adenoviruses (HAdVs) are pathogens of clinical importance and often used as model to understand biological systems 1. Therefore, further research on HAdVs, particularly among susceptible groups, is needed and continuous surveillance is required for public health preparedness including outbreak investigations. Our findings confirm that recombination among HAdVs is important for molecular evolution and emergence of new strains. The incidence of potential recombination events was higher in severe cases than in mild cases. This isolate showed intertypic recombination events involving four genotypes, had the highest homology to HAdV89 at complete genome level, but possessed the fiber gene of HAdV1, thereby representing a novel genotype of HAdV species C. Clustering of the HAdV whole-genome sequences of the severe and mild cases did not show any differences except for one sample (isolated from a patient presenting with sepsis, meningitis, and hospitalization) that formed its own cluster with HAdV species C genotypes. The HAdV species implicated in causing severe infections in this study included HAdV species C genotypes (HAdV1, HAdV2, and HAdV5). Using whole-genome sequencing (WGS), we investigated whether there were any differences between circulating HAdV strains associated with severe infections (meningitis, sepsis, convulsion, sudden infant death syndrome, death, and hospitalization) and mild clinical presentations in pediatric patients hospitalized between the years 19 in a tertiary care hospital group in Bern, Switzerland covering a population base of approx. Studies on comparative viral genomic analysis of cases associated with severe and mild infections due to HAdV are limited. Human adenoviruses (HAdVs) are highly contagious pathogens of clinical importance, especially among the pediatric population.
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